Platelet-Rich Fibrin (PRF) is a next-generation regenerative treatment that harnesses your body’s natural healing abilities to rejuvenate the skin, promote collagen production, and restore a youthful glow—all without synthetic additives or chemicals.
By using a concentrated blend of platelets, white blood cells, and fibrin from your own blood, PRF promotes natural tissue regeneration, making it an effective solution for skin rejuvenation, volume loss, acne scars, and under-eye hollows.
At Metropolis Dermatology in Pasadena, we specialize in PRF therapy as part of our advanced, non-surgical skincare offerings to help you achieve radiant, healthy skin with natural-looking results.
What is PRF (Platelet-Rich Fibrin)?
PRF is a 100% autologous, injectable treatment derived from your own blood. After a simple blood draw, the sample is spun in a centrifuge at a lower speed than traditional PRP (Platelet-Rich Plasma), preserving more regenerative cells such as leukocytes, platelets, and fibrin.
These components work together to create a natural fibrin matrix that gradually releases growth factors over time, enhancing tissue repair, stimulating collagen production, and improving skin texture and elasticity. Unlike PRP, PRF does not contain anticoagulants or additives, making it a more natural and slower-releasing treatment—ideal for individuals seeking long-lasting, biocompatible rejuvenation.
Common Treatment Areas
PRF is a versatile treatment that can be used alone or in combination with other procedures to address various skin concerns:
- Under-Eyes. Softens dark circles and hollows while thickening the delicate under-eye skin.
- Cheeks & Midface. Restores volume and improves skin quality for a fuller, smoother look.
- Fine Lines & Wrinkles. Reduces the appearance of crow’s feet, smile lines, and other expression lines.
- Scars & Texture. Minimizes acne scars and enhances skin tone and smoothness.
Target Concerns
PRF therapy addresses several dermatologic and cosmetic concerns by leveraging the body’s natural regenerative mechanisms:
- Volume Loss. Gradually restores lost volume in delicate areas, such as the tear troughs and cheeks, for a more youthful appearance.
- Skin Laxity. Improves skin firmness and elasticity through natural collagen production.
- Dull or Aging Skin. Revitalizes tired-looking skin with improved tone, hydration, and cellular turnover.
- Acne Scars. Promotes tissue remodeling and regeneration to smooth out depressed or textured scars.
What to Expect During Treatment
PRF therapy begins with a quick blood draw, after which your sample is placed into a centrifuge to isolate the platelet-rich fibrin. Once prepared, the PRF is carefully injected into targeted areas using a fine needle or microcannula. The entire session typically takes about 45 to 60 minutes. Numbing cream may be applied beforehand to enhance comfort. Since PRF is derived entirely from your own body, the risk of allergic reaction or adverse effects is extremely low.
How Long Do Results Last?
Because PRF works gradually to stimulate collagen and regenerate tissue, results appear more naturally over time. You may start noticing improvements within a few weeks, with optimal results typically visible after 2 to 3 sessions spaced a month apart. The benefits can last 6 to 12 months or longer, especially when supported with good skincare and healthy lifestyle choices. Periodic maintenance sessions are recommended to sustain long-term improvements.
Who Are the Ideal Candidates?
PRF is suitable for individuals looking for a natural, chemical-free treatment to rejuvenate their skin or address early signs of aging and volume loss. It’s especially ideal for those with:
- Sensitivity to synthetic fillers
- Concerns in delicate areas like under the eyes
- A preference for natural, regenerative treatments
FAQs
Is PRF safe?
Yes. Since PRF is created from your own blood without additives, it carries an extremely low risk of side effects or allergic reactions.
How is PRF different from PRP?
PRF is spun at a lower speed, preserving more white blood cells and forming a fibrin matrix that allows for slower, longer-lasting release of growth factors compared to PRP.
Is there any downtime?
Downtime is minimal. You may experience mild swelling or bruising at the injection site, which usually resolves within a few days.
Can PRF be combined with other treatments?
Absolutely. PRF pairs well with microneedling, dermal fillers, and laser treatments to enhance skin rejuvenation and maximize results.
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If you’re ready to rejuvenate your skin with a natural, regenerative solution, PRF therapy at Metropolis Dermatology in Pasadena, CA, offers a safe and effective way to restore your youthful glow—no synthetic fillers required. Book your consultation today and discover how PRF can elevate your skin health from the inside out!